May 3rd, 2024
Natural Killer (NK) cells, when exposed to antibody treatment used against HER2-positive breast cancer, secrete specific types of cytokines that activate the immune response against tumor cells. Researchers have confirmed that patients with NK lymphocytes present in the tumor environment show a better response to treatment, thanks to this mechanism. This confirms the feasibility of using cytokines secreted by NK cells as markers of response to anti-HER2 antibodies with a simple blood test. It also reaffirms various clinical trials using these lymphocytes to bolster treatment in patients with metastatic HER2-positive breast cancer.
February 23rd, 2023
A collaborative effort led by Dr. Anna Bigas, from the Hospital del Mar Research Institute and Josep Carreras Leukaemia Research Institute, found that the population of haematopoietic stem cells (HSC) responsible for the generation and self-renewal of the blood and immune system keeps a long-term undifferentiated state thanks to its ability to physically block its own NOTCH1 receptor through the expression of JAGGED1, a specific NOTCH activator. Authors hypothesise that the lack of this previously unknown mechanism might be the cause for the poor performance of current approaches to generate haematopoietic stem cells from induced pluripotent stem cells for regenerative medicine.
Read more sobre "Finded Notch self-inhibition keeps haematopoietic stem cells from differentiate"
February 21st, 2024
This is an international collaborative work coordinated by the Hospital del Mar Research Institut and the Hospital Clínic-IDIBAPS, published in the Journal of Neurology. This new tool may make it possible to adapt the monitoring and treatment of patients to their future evolution, opting for the most effective, but with more possible side effects in those with worse prognosis. The exact factors behind the progression of disability in multiple sclerosis, a disease with great heterogeneity, are unknown, which is why it is so important to have tools of this type.
21 de maig de 2024
7 de junio de 2024
31 de mayo del 2024
Parc Salut Mar
Passeig Marítim 25-29 Barcelona 08003
See location on Google maps
Phone: 93 248 30 00 · Fax: 93 248 32 54
Information request
© 2006 - 2024 Parc de Salut Mar · Legal notice and Privacy Police | Cookie Policy | Accessibility